IL-4 Can Inhibit IL-17 Production in Collagen Induced Arthritis
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Abstract:
Background: IL-4 is a cytokine that induces differentiation of naive helper T cells into Th2 cells. Once activated by IL-4, Th2 cells subsequently produce additional IL-4. Objective: To examine the effect of IL-4 on IL-17 production and its effect in Collagen- Induced Arthritis (CIA) mice. Method: In this study, a chicken collagen-II-induced experimental arthritis (CIA) model was used in DBA/1 mice to investigate the relationship between IL-4 and IL-17 as well as other inflammatory factors. On the 38th day after the mice were induced with CIA, the expression of IL-17 and IL-4 as well as IFN-γ and IL-13 in sera of the mice was measured by QRT-PCR and ELISA. Result: The result of QRT-PCR analysis of IL-17 and IL-4 mRNA levels in the spleen showed that IL-17 is increased significantly at the onset of CIA in the spleen (p
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il-4 can inhibit il-17 production in collagen induced arthritis
background: il-4 is a cytokine that induces differentiation of naive helper t cells into th2 cells. once activated by il-4, th2 cells subsequently produce additional il-4. objective: to examine the effect of il-4 on il-17 production and its effect in collagen- induced arthritis (cia) mice. method: in this study, a chicken collagen-ii-induced experimental arthritis (cia) model was used in dba/1 ...
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BACKGROUND IL-4 is a cytokine that induces differentiation of naive helper T cells into Th2 cells. Once activated by IL-4, Th2 cells subsequently produce additional IL-4. OBJECTIVE To examine the effect of IL-4 on IL-17 production and its effect in Collagen-Induced Arthritis (CIA) mice. METHOD In this study, a chicken collagen-II-induced experimental arthritis (CIA) model was used in DBA/1 ...
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Journal title
volume 8 issue 4
pages 209- 217
publication date 2011-12-01
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